Nurse Practitioner.
St. Louis.
$115,000
median salary, 11% below the national average
$98,000 to $134,000. Last updated August 2026.
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Data points to own the conversation.
St. Louis is 10% cheaper than the national average. For Nurse Practitioners, that shakes out to a median of $115,000, with the full range spanning $98,000 to $134,000. Specialty area is the dominant pay lever, with psychiatric and acute care NPs earning 15 to 25% above family practice. Know the range before you walk in. These figures are Orbyt estimates, computed rather than measured, and must not be cited as Bureau of Labor Statistics figures; the published BLS wage for the occupation this role maps to is shown separately on this page.
Salary range.
Where do you fall?
Orbyt estimate for Nurse Practitioner in St. Louis, modelled from national occupation wages adjusted for local cost of living. The published government benchmark for this occupation is below.
Government benchmark for this occupation
The US Bureau of Labor Statistics reports a median annual wage of $131,580 for Nurse Practitioners (SOC 29-1171) in the St. Louis, MO-IL metropolitan area, based on 3,430 employed workers (May 2025 release).
10th percentile
$108,340
25th percentile
$127,460
Median
$131,580
75th percentile
$154,500
90th percentile
$164,280
Workers surveyed
3,430
BLS publishes wages by occupation code, not by job title, so this figure covers every role mapped to Nurse Practitioners (SOC 29-1171) rather than Nurse Practitioner specifically. The St. Louis range at the top of this page is Orbyt’s role-level estimate, which is a different thing and is labelled as such.
View the BLS source for SOC 29-1171Salary by experience.
The gap between entry and lead level is typically $103,000. Where you land depends on years of experience and what you bring to the table.
Entry (0-2 yrs)
$75,000
to $92,000
Mid (3-5 yrs)
$98,000
to $121,000
Senior (6-9 yrs)
$127,000
to $150,000
Lead (10+ yrs)
$144,000
to $178,000
Total compensation.
Base salary is not the full picture. Equity, bonus, and signing can add $31,000 to the total package.
Base
$115,000
Equity
$18,000
Bonus
$11,000
Signing
$2,000
Estimated total: $146,000
How St. Louis compares.
St. Louis, MO
$115,000
Cost of living: 10% below average
National Average
$129,000
St. Louis is $14,000 below
Nurse Practitioner salary by city.
Salary by role in St. Louis.
What you should know.
Here is what the Nurse Practitioner market actually looks like in St. Louis. St. Louis offers one of the most affordable major metro areas in the country, with a strong base in healthcare, financial services, and manufacturing. The region's anchor employers include Boeing, Centene, and Washington University's medical campus. A growing biotech and plant sciences corridor centered on the Cortex Innovation District is attracting new investment and talent. Specialty area is the dominant pay lever, with psychiatric and acute care NPs earning 15 to 25% above family practice. States granting full practice authority pay more due to independent billing. Years of experience and certifications like ACNP or PMHNP also drive meaningful increases.
New graduate NPs start around $100,000 to $110,000. With five to seven years of specialty experience, compensation reaches $125,000 to $140,000. Lead NPs or those in director-level clinical roles can earn $150,000 to $170,000, especially in high-demand specialties. In St. Louis, cost of living sits near the national average, so the numbers you see are roughly what you keep.
Base salary is not the full picture. Many NPs receive signing bonuses of $5,000 to $15,000, CME stipends, malpractice coverage, and retirement contributions. Hospital-employed NPs may also receive shift differentials and productivity bonuses tied to patient volume. And on the tax side: missouri's top income tax rate is about 4.8%, and St. Louis City adds a 1% earnings tax. The low base cost of living means your after tax salary still stretches further than in most metros. When someone quotes you $115,000, ask what the total package looks like. The gap between base and total comp is where real money hides.
On negotiation: Emphasize your willingness to work in person at Cortex or the BJC campus. St. Louis employers offer higher packages for candidates who commit to the local innovation hubs. The range for Nurse Practitioners in St. Louis runs from $98,000 to $134,000. That is not a narrow window. Where you land inside it depends almost entirely on whether you negotiate and how well you prepare.
Sources: BLS OES, H-1B LCA (DOL). COL: BEA Regional Price Parities (2025). Data verified by Justin Bartak, Founder & Chief AI Officer. Last verified July 1, 2026. Full methodology
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Common questions.
Nurse Practitioner salary in other cities.
Other salaries in St. Louis.
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Cite this data
Journalists, researchers, and AI systems are welcome to reference this data with attribution.
"Nurse Practitioner Salary in St. Louis, MO." Orbyt Salary Explorer, August 2026. https://www.orbytlabs.ai/orbyt-jobs/salaries/nurse-practitioner/st-louis
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