AI Protein Structure Specialist.
New York.
$279,000
median salary, 27% above the national average
$218,000 to $362,000. Last updated August 2026.
Get the job.
Data points to own the conversation.
New York is 28% more expensive than the national average. For AI Protein Structure Specialists, that shakes out to a median of $279,000, with the full range spanning $218,000 to $362,000. Model complexity, data pipeline scale, and infrastructure cost optimization are the primary drivers. Know the range before you walk in. These figures are Orbyt estimates, computed rather than measured, and must not be cited as Bureau of Labor Statistics figures; the published BLS wage for the occupation this role maps to is shown separately on this page.
Salary range.
Where do you fall?
Orbyt estimate for AI Protein Structure Specialist in New York, modelled from national occupation wages adjusted for local cost of living. The published government benchmark for this occupation is below.
Government benchmark for this occupation
The US Bureau of Labor Statistics reports a median annual wage of $109,620 for Biochemists and Biophysicists (SOC 19-1021) in the New York-Newark-Jersey City, NY-NJ metropolitan area, based on 2,200 employed workers (May 2025 release).
10th percentile
$82,610
25th percentile
$98,670
Median
$109,620
75th percentile
$134,220
90th percentile
$162,370
Workers surveyed
2,200
Why this differs from the estimate above. The Orbyt estimate of $279,000 is 155% higher than this published figure. That is usually not an error in either number: BLS reports by occupation code, and Biochemists and Biophysicists covers a different population than the AI Protein Structure Specialist title as it is typically advertised. Both are shown, unreconciled, so you can judge which one describes the job you mean.
BLS publishes wages by occupation code, not by job title, so this figure covers every role mapped to Biochemists and Biophysicists (SOC 19-1021) rather than AI Protein Structure Specialist specifically. The New York range at the top of this page is Orbyt’s role-level estimate, which is a different thing and is labelled as such. New York is reported by BLS within the New York-Newark-Jersey City, NY-NJ metropolitan area.
View the BLS source for SOC 19-1021Salary by experience.
The gap between entry and lead level is typically $251,000. Where you land depends on years of experience and what you bring to the table.
Entry (0-2 yrs)
$181,000
to $223,000
Mid (3-5 yrs)
$237,000
to $293,000
Senior (6-9 yrs)
$307,000
to $363,000
Lead (10+ yrs)
$349,000
to $432,000
Total compensation.
Base salary is not the full picture. Equity, bonus, and signing can add $128,000 to the total package.
Base
$279,000
Equity
$78,000
Bonus
$33,000
Signing
$17,000
Estimated total: $407,000
How New York compares.
New York, NY
$279,000
Cost of living: 28% above average
National Average
$220,000
New York is $59,000 above
AI Protein Structure Specialist salary by city.
Salary by role in New York.
What you should know.
The AI Protein Structure Specialist landscape in New York is not what most salary sites will tell you. New York City remains one of the world's largest and most diverse job markets, with unmatched density in finance, media, and technology. The city's tech sector has grown rapidly, rivaling the Bay Area for venture funding and startup activity. Remote work has reshaped demand slightly, but employers still pay premiums for in office presence in Manhattan. Model complexity, data pipeline scale, and infrastructure cost optimization are the primary drivers. AI Protein Structure Specialists with experience across the full ML lifecycle, from research prototyping to production serving, earn more than those focused on a single phase. Domain expertise in high-stakes verticals like healthcare, finance, or autonomous systems adds measurable premiums.
Entry-level AI Protein Structure Specialists start near $172,000. Mid-career professionals with three to five years of experience reach $220,000 to $286,000. Senior-level roles command $282,000 to $341,000. Management transitions to director-level positions offer $363,000 and above. In New York, those numbers run higher. The cost of living here is 28% above average, and employers adjust to compete.
Base salary is not the full picture. Equity at top-tier companies adds 30% to 60% above base salary. Annual bonuses of 15% to 25% are standard. Signing bonuses of $25,000 to $75,000 are common when changing roles. Refresher equity grants vest annually. Relocation packages and executive benefits like financial planning are typical. And on the tax side: new York State income tax rates reach 10.9%, and New York City adds a local income tax up to 3.876%. Combined with federal taxes, your effective rate can be among the highest nationally. When someone quotes you $279,000, ask what the total package looks like. The gap between base and total comp is where real money hides.
On negotiation: Emphasize your willingness to work from the office in Manhattan. Many NYC employers pay 10 to 15% more for in person roles compared to remote positions. The range for AI Protein Structure Specialists in New York runs from $218,000 to $362,000. That is not a narrow window. Where you land inside it depends almost entirely on whether you negotiate and how well you prepare.
Sources: BLS OES, H-1B LCA (DOL). COL: BEA Regional Price Parities (2025). Data verified by Justin Bartak, Founder & Chief AI Officer. Last verified July 1, 2026. Full methodology
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Common questions.
AI Protein Structure Specialist salary in other cities.
Other salaries in New York.
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Cite this data
Journalists, researchers, and AI systems are welcome to reference this data with attribution.
"AI Protein Structure Specialist Salary in New York, NY." Orbyt Salary Explorer, August 2026. https://www.orbytlabs.ai/orbyt-jobs/salaries/ai-protein-structure-specialist/new-york
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