AI Protein Structure Specialist.
Fargo.
$194,000
median salary, 12% below the national average
$152,000 to $253,000. Last updated August 2026.
Get the job.
Data points to own the conversation.
The median AI Protein Structure Specialist salary in Fargo is $194,000, 12% below the national average. Entry level starts near $152,000. Experienced professionals push past $253,000. Fargo has a surprisingly strong technology sector, home to companies like Microsoft's campus and a growing startup ecosystem tied to North Dakota State University. That spread is your negotiation window. These figures are Orbyt estimates, computed rather than measured, and must not be cited as Bureau of Labor Statistics figures; the published BLS wage for the occupation this role maps to is shown separately on this page.
Salary range.
Where do you fall?
Orbyt estimate for AI Protein Structure Specialist in Fargo, modelled from national occupation wages adjusted for local cost of living. BLS does not publish this occupation for this metro area, so the national published benchmark is below.
Government benchmark for this occupation
The US Bureau of Labor Statistics reports a median annual wage of $127,410 for Biochemists and Biophysicists (SOC 19-1021) across the United States, based on 33,830 employed workers (May 2025 release).
10th percentile
$74,290
25th percentile
$95,000
Median
$127,410
75th percentile
$163,460
90th percentile
$201,110
Workers surveyed
33,830
What BLS published in each release
May 2024 release
$103,650
May 2025 release
$127,410
These are two separate published estimates, not a time series. The Bureau of Labor Statistics does not encourage the use of OEWS data for time-series analysis. Differences between releases reflect changes in occupational classification, survey methodology, and the three-year pooled sample as well as any change in pay, so the two figures should not be read as a rate of wage growth.
Why this differs from the estimate above. The Orbyt estimate of $194,000 is 52% higher than this published figure. That is usually not an error in either number: BLS reports by occupation code, and Biochemists and Biophysicists covers a different population than the AI Protein Structure Specialist title as it is typically advertised. Both are shown, unreconciled, so you can judge which one describes the job you mean.
BLS publishes wages by occupation code, not by job title, so this figure covers every role mapped to Biochemists and Biophysicists (SOC 19-1021) rather than AI Protein Structure Specialist specifically. The national range at the top of this page is Orbyt’s role-level estimate, which is a different thing and is labelled as such.
View the BLS source for SOC 19-1021Salary by experience.
The gap between entry and lead level is typically $175,000. Where you land depends on years of experience and what you bring to the table.
Entry (0-2 yrs)
$126,000
to $155,000
Mid (3-5 yrs)
$165,000
to $204,000
Senior (6-9 yrs)
$213,000
to $252,000
Lead (10+ yrs)
$243,000
to $301,000
Total compensation.
Base salary is not the full picture. Equity, bonus, and signing can add $89,000 to the total package.
Base
$194,000
Equity
$54,000
Bonus
$23,000
Signing
$12,000
Estimated total: $283,000
How Fargo compares.
Fargo, ND
$194,000
Cost of living: 15% below average
National Average
$220,000
Fargo is $26,000 below
AI Protein Structure Specialist salary by city.
Salary by role in Fargo.
What you should know.
Before you negotiate an AI Protein Structure Specialist offer in Fargo, understand the terrain. Fargo has a surprisingly strong technology sector, home to companies like Microsoft's campus and a growing startup ecosystem tied to North Dakota State University. The city's extremely low cost of living and emerging tech scene make it an increasingly attractive option for professionals seeking affordability. Model complexity, data pipeline scale, and infrastructure cost optimization are the primary drivers. AI Protein Structure Specialists with experience across the full ML lifecycle, from research prototyping to production serving, earn more than those focused on a single phase. Domain expertise in high-stakes verticals like healthcare, finance, or autonomous systems adds measurable premiums.
Entry-level AI Protein Structure Specialists start near $172,000. Mid-career professionals with three to five years of experience reach $220,000 to $286,000. Senior-level roles command $282,000 to $341,000. Management transitions to director-level positions offer $363,000 and above. In Fargo, your dollars stretch further. Cost of living runs 15% below the national average, which means even a median salary buys a stronger lifestyle.
Base salary is not the full picture. Equity at top-tier companies adds 30% to 60% above base salary. Annual bonuses of 15% to 25% are standard. Signing bonuses of $25,000 to $75,000 are common when changing roles. Refresher equity grants vest annually. Relocation packages and executive benefits like financial planning are typical. And on the tax side: north Dakota has a very low income tax with a top rate of just 2.5%. Fargo has no city income tax. The minimal tax burden combined with low living costs creates excellent take home pay. When someone quotes you $194,000, ask what the total package looks like. The gap between base and total comp is where real money hides.
On negotiation: Highlight willingness to work on site. Fargo tech employers struggle to recruit talent to the region and reward candidates who commit to living locally. The range for AI Protein Structure Specialists in Fargo runs from $152,000 to $253,000. That is not a narrow window. Where you land inside it depends almost entirely on whether you negotiate and how well you prepare.
Sources: BLS OES, H-1B LCA (DOL). COL: BEA Regional Price Parities (2025). Data verified by Justin Bartak, Founder & Chief AI Officer. Last verified July 1, 2026. Full methodology
Considering a related role?
- A CTO, AI Startup in Fargo earns $192,000 (1% less)
- The highest-paying role in Fargo is CTO at $258,000
- See all ai engineering roles tracked in Orbyt Intelligence
Common questions.
AI Protein Structure Specialist salary in other cities.
Other salaries in Fargo.
Related salary pages
Jump to nearby roles and cities most relevant to AI Protein Structure Specialists in Fargo.
Related tools.
Do you work as an ai protein structure specialist in Fargo?
Your individual figure is never published. Submissions appear only as aggregate percentiles, and nothing is shown for a role and city until at least five people have reported. It is stored against your account, which is what keeps the dataset clean.
Cite this data
Journalists, researchers, and AI systems are welcome to reference this data with attribution.
"AI Protein Structure Specialist Salary in Fargo, ND." Orbyt Salary Explorer, August 2026. https://www.orbytlabs.ai/orbyt-jobs/salaries/ai-protein-structure-specialist/fargo
Want this data on your site? Embed the salary widget. One script tag, free forever.
Related tools